At present, the domestic cross-border e-commerce in the background of the Internet is such as fire and tea rapidly into the exhibition and growth, with the gradual expansion of the scale of cross-border e-commerce industry, the demand for cross-border e-commerce talent is also increasing, the international economy and trade major of the School of Applied Technology of Soochow University according to the latest market demand. Based on the teaching mode of combining economic and trade advantages and e-commerce skills, combining work with study and progressive ability, the training objective, professional positioning and training mode of talents are studied. The course teaching module and school-enterprise cooperation and other aspects are analyzed. Thus, the practical problem of talent gap of cross-border e-commerce merchants is solved.